Tablet Manufacturer/Distributor: Square Pharmaceuticals Ltd. Generic Name: Piracetam 800 mg Tablet
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Indications
Cerebral vascular accidents and cerebral insufficiencies: Ischaemic or even haemorrhagic acute accidents, chronic manifestations of the above accidents or of cerebral atherosclerosis. Mental retardation in children: Ease of resuming individual contact, sociability and learning, improved intellectual performances and school results. Behaviour and psychotic problems in old age: Memory deficits, particularly with regard to fixation and evocation asthenia adaption disorders, disturbed psychomotor reactions.
Pharmacology
Piracetam is a 'nootrope', that is to say, it is a psychotropic agent which acts directly on the brain to improve the efficacy of the telencephalon in both normal subjects and those suffering from some functional deficit. This area of the brain is involved in cognition and also has a role to play in learning and memory, in alertness and in consciousness. Piracetam does not produce either sedation or stimulation. Piracetam can act on the central nervous system in a variety of ways. It modifies neurotransmission within the brain, and can help to improve the metabolic environment essential for good neuronal function. It is also a haemorrheological agent and can improve microcirculation without producing vasodialation. When given as acute or long term treatment for patients' suffering from a functional CNS deficit, it heightens alertness and increase cognitive function. Piracetam protects and restores cognitive functional capacity for cerebral trauma, e.g. hypoxia or intoxication, and after electroshock therapy. Piracetam may be given alone or together with other drugs when treating myoclonia due to anoxia. It reduces the duration of vestibular nystagamus.
Dosage & Administration
Adults: In cerebro-cortical insufficiency disorders, usual dose is 800 mg 3 times a day. In myoclonic seizures, a dose of 7.2 gm daily, increasing by 4.8 gm per day every 3 to 4 days up to maximum of 20 gm daily, given in 2 or 3 divided doses.
Children: The daily dosage depends on the weight of the child, 50 mg/kg of body weight in 3 divided doses. Once the desired results has been obtained, reduce the initial dose by half.
Interaction
In a single case, disarray, fractiousness and rest disarranges were detailed in concomitant utilize with thyroid extricate. At display, no interaction has been watched with the taking after anti-epileptic drugs, clonazepam, carbamazepine, phenyton, phenobarbitone and sodium valporate, based on a little number of considers.
Contraindications
Piracetam is contra-indicated in patients with severe renal insufficiency (creatinine clearance < 20 ml/min) and hepatic impairment. As the principal route of elimination for Piracetam is via the kidney, special care must be taken when treating patients known to suffer from renal insufficiency. Monitoring of renal function is recommended in such cases. The increase in half-life is directly related to the decrease in renal function and creatinine clearance. This is also true for the older patient in whom creatinine clearance is dependent on age.
Side Effects
The side impacts detailed incorporate apprehension, tumult, peevishness, uneasiness and rest unsettling influences. The rate of these amid clinical trials was (≤ 5%) and they were more frequently famous within the more seasoned patients taking > 2.4 gm every day. Within the majority of cases, a dosage decrease sufficed to create these indications vanish. A few patients may complain of weariness or tiredness, gastrointestinal issues, e.g. sickness, heaving, the runs and stomachache have moreover been detailed but their rate amid clinical trials was ≤ 2%. Other side effects e.g. vertigo, migraine, trembling and sexual incitement have sometimes been detailed.
Pregnancy & Lactation
Piracetam should not be prescribed during pregnancy or when breast feeding, except under exceptional circumstances. Piracetam is able to cross the placenta.
Precaution and Warning
Blood urea nitrogen and creatinine levels should be monitored regularly in patients with kidney impairment.
Liver enzymes and related parameters must be monitored to asses the liver function during treatment with piracetam.
Caution is required in treating patients with severe heart disease, the elderly or people with bleeding problems or who have recently undergone surgery.
Piracetam may cause drowsiness and the user should not carry our skilled tasks such as driving or operating heavy machinery.
Abrupt withdrawal of the medication should be avoided.
Therapeutic Class
Aide anti-epileptic drugs, Drugs used in tremor, tics & related disorder
Storage Conditions
Store in a cool and dry place at a temperature below 30°C, Keep away from sunlight. Keep out of the reach of children
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